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0:12 Building Blocks for Treatment Plan
0:42 Who is the lecture for?
0:51 Advanced Cancer outside the Prostate
1:03 What is the problem?
1:27 Oversimplification?
1:49 Too many diagnostic options?
1:59 Multiplicity of practice and business models?
2:24 Misunderstood terms and concepts?
2:40 Outdated perceptions?
3:04 Too much information
3:30 Goals of this presentation
4:02 The Basics of Advanced Prostate Cancer
6:13 “Updated” Biology of Advanced Prostate Cancer
6:38 “Clonal” theory of Cancer
6:45 The Heterogeneity of Prostate Cancer Cells
10:20 Systemic treatments as of 2023
10:48 What is a systemic therapy?
11:28 Suppressive therapies
13:05 Cytotoxic therapies
14:12 Mechanism of Action (MOA)
14:52 Testosterone promotes prostate cancer growth
16:01 GnRH Hormone Therapy
16:27 Anti-Androgen Hormone Therapy
16:58 Hormone (Castrate) Resistant Prostate Cancer
17:28 ARPI Hormone Therapy
18:55 Chemotherapy
19:55 Immunotherapy
20:37 Radioligand Therapy
21:40 What’s the best way to create a treatment plan?
25:03 Abbreviations pertaining to forms of therapy
25:46 Case study: Newly diagnosed Advanced Prostate Cancer
27:39 Triple therapy
28:51 What if you didn’t start with Triple Therapy?
29:48 Case 1: Failing HT?
32:51 Chemotherapy first
34:12 Case 2: Failing HT + ARPI?
38:50 Less differentiated = more aggressive cancer = LESS PSA & PSMA
39:36 PSA Zero
40:24 Case 3: Failing HT + prior CHtx?
42:19 Case 4: Failing HT + ARPI + prior CHtx?
45:35 Proper “care and feeding” of your treatment plan
46:00 Regular and comprehensive follow up is key
47:13 Prior genetic testing
49:36 Updating genetic testing
50:43 Mutations relevant to PARPi
52:13 Mutations relevant to immunotherapy
54:07 Mutations relevant to PARPi or immunotherapy
57:05 Regular and comprehensive follow summary
57:24 Direct treatments as of 2023
58:15 DIY Combat Manual for Beating Prostate Cancer Videos
59:02 Multiple ways that residual disease can be eliminated
59:21 Chest surgery example
59:47 Radiation therapy example
1:01:25 Minimal invasive procedures
1:02:33 Misunderstood concepts
1:03:18 Stand-of-Care
1:05:11 Guidlines
1:05:58 Clinical trials
1:09:43 Oversimplified view of disease
1:10:08 List to bring to with you to physician meetings
1:10:48 Dr. Kwon’s Team

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Who we are:

The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at or contact our free helpline with any questions that you have at Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.


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